PT  - JOURNAL ARTICLE
AU  - G Klopman
AU  - E Buyukbingol
TI  - An artificial intelligence approach to the study of the structural moieties relevant to drug-receptor interactions in aldose reductase inhibitors.
DP  - 1988 Dec 01
TA  - Molecular Pharmacology
PG  - 852--862
VI  - 34
IP  - 6
4099  - http://molpharm.aspetjournals.org/content/34/6/852.short
4100  - http://molpharm.aspetjournals.org/content/34/6/852.full
SO  - Mol Pharmacol1988 Dec 01; 34
AB  - The computer-automated structure evaluation program has been used to study 482 compounds relevant to the inhibition of the aldose reductase enzyme. Major activating/inactivating fragments were generated automatically. The significance of these molecular descriptors with respect to the activity of the compounds is discussed.