TY - JOUR T1 - An artificial intelligence approach to the study of the structural moieties relevant to drug-receptor interactions in aldose reductase inhibitors. JF - Molecular Pharmacology JO - Mol Pharmacol SP - 852 LP - 862 VL - 34 IS - 6 AU - G Klopman AU - E Buyukbingol Y1 - 1988/12/01 UR - http://molpharm.aspetjournals.org/content/34/6/852.abstract N2 - The computer-automated structure evaluation program has been used to study 482 compounds relevant to the inhibition of the aldose reductase enzyme. Major activating/inactivating fragments were generated automatically. The significance of these molecular descriptors with respect to the activity of the compounds is discussed. ER -