%0 Journal Article %A LARS TERENIUS %T SH-Groups Essential for Estrogen Uptake and Retention in the Mouse Uterus %D 1967 %J Molecular Pharmacology %P 423-428 %V 3 %N 5 %X The effect of various sulfhydryl reagents on the uptake and retention of estrogens by the mouse uterus in vitro has been studied. It was found that N-ethylmaleimide and p-chloromercuribenzoate blocked the uptake and retention of 17β-estradiol by the uterus in vitro while iodoacetate blocked the uptake but not the retention of 17β-estradiol. N-Ethylmaleimide also blocked the uterine uptake and retention of the synthetic estrogen meso-hexestrol. On the other hand, it had no effect on the uptake and retention of the less estrogenic stereoisomer racemic-hexestrol. Estrogen concentration in a "nontarget" tissue, the diaphragm, was essentially unaffected by the sulfhydryl inhibitors. ACKNOWLEDGMENTS I would like to thank Mrs. Carola Engström for excellent technical assistance. The work was supported by a grant from the Swedish Cancer Society. %U https://molpharm.aspetjournals.org/content/molpharm/3/5/423.full.pdf