PT  - JOURNAL ARTICLE
AU  - TERENIUS, LARS
TI  - SH-Groups Essential for Estrogen Uptake and Retention in the Mouse Uterus
DP  - 1967 Sep 01
TA  - Molecular Pharmacology
PG  - 423--428
VI  - 3
IP  - 5
4099  - http://molpharm.aspetjournals.org/content/3/5/423.short
4100  - http://molpharm.aspetjournals.org/content/3/5/423.full
SO  - Mol Pharmacol1967 Sep 01; 3
AB  - The effect of various sulfhydryl reagents on the uptake and retention of estrogens by the mouse uterus in vitro has been studied. It was found that N-ethylmaleimide and p-chloromercuribenzoate blocked the uptake and retention of 17β-estradiol by the uterus in vitro while iodoacetate blocked the uptake but not the retention of 17β-estradiol. N-Ethylmaleimide also blocked the uterine uptake and retention of the synthetic estrogen meso-hexestrol. On the other hand, it had no effect on the uptake and retention of the less estrogenic stereoisomer racemic-hexestrol. Estrogen concentration in a "nontarget" tissue, the diaphragm, was essentially unaffected by the sulfhydryl inhibitors. ACKNOWLEDGMENTS I would like to thank Mrs. Carola Engström for excellent technical assistance. The work was supported by a grant from the Swedish Cancer Society.