RT Journal Article
SR Electronic
T1 Effects of 5-Methylpyrazole-3-Carboxylic Acid on Adipose Tissue
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 442
OP 452
VO 3
IS 5
A1 FROESCH, E. R.
A1 WALDVOGEL, M.
A1 MEYER, U. A.
A1 JAKOB, A.
A1 LABHART, A.
YR 1967
UL http://molpharm.aspetjournals.org/content/3/5/442.abstract
AB 5-Methylpyrazole-3-carboxylic acid stimulated the incorporation of labeled glucose into adipose tissue in vivo without stimulating the incorporation of labeled glucose into glycogen of the diaphragm and without increasing the glucose turnover of normal rats to any significant degree. Nicotinic acid shared with 5-methylpyrazole-3-carboxylic acid these effects on adipose tissue metabolism. 5-Methylpyrazole-3-carboxylic acid blocked the rise of the plasma free fatty acids and partially prevented the rise of the blood sugar in acutely insulin-deficient rats due to the maintenance of a normal utilization of glucose by the tissues (muscle) despite insulin deficiency. After prolonged treatment with 5-methylpyrazole-3-carboxylic acid an escape phenomenon was observed. 5-Methylpyrazole-3-carboxylic acid still acutely depressed the level of free fatty acids, but the effect was short lived. 5-Methylpyrazole-3-carboxylic acid stimulated incorporation of glucose into glycerides of adipose tissue more markedly and more rapidly in pretreated than in normal rats, but the fatty acids and glycerides synthesized from glucose left the tissue again more rapidly. ACKNOWLEDGMENT This work was supported by grants from the United States Public Health Service (AM 5387) and from the Schweizerische Nationalfonds (3854).