RT Journal Article
SR Electronic
T1 The Mode of Action of Levallorphan as an Inhibitor of Cell Growth
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 453
OP 472
VO 3
IS 5
A1 GREENE, RICHARD
A1 MAGASANIK, BORIS
YR 1967
UL http://molpharm.aspetjournals.org/content/3/5/453.abstract
AB Levallorphan inhibits the synthesis of RNA, DNA, and protein by Escherichia coli. The drug was found to cause an immediate, dramatic decrease in the amount of intracellular ATP. Evidence is presented which suggests that the decrease in ATP concentration is a consequence of the stimulation of an ATPase. Similar results were obtained in HeLa cells treated with levallorphan. ACKNOWLEDGMENT This work was supported by Research Grants CY-5210 and GM-7446 from the U.S. Public Health Service. During the course of this work Richard Green was the recipient of a Postdoctoral Fellowship 1 F2 AM-19,349 of the U.S. Public Health Service.