RT Journal Article
SR Electronic
T1 Metabolic Integrity of Deoxyribonucleohistones during Enzyme Induction
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 303
OP 305
VO 3
IS 3
A1 PAUL BYVOET
YR 1967
UL http://molpharm.aspetjournals.org/content/3/3/303.abstract
AB Previous work has shown that after individual labeling of histone and DNA of various normal and neoplastic tissues of the rat, the first-order decay rates of their respective specific activities were approximately similar. The present studies indicate that the normal turnover of histones in liver parenchymal cells is not altered during periods of alternate enzyme induction and repression resulting from dietary changes or drug injections. ACKNOWLEDGMENTS This research was supported by U. S. National Institutes of Health Grant CA-18402, CY-6506 and an American Cancer Society Institutional Grant.