@article {Fernandez-Larsson766, author = {R Fernandez-Larsson and J L Patterson}, title = {Ribavirin is an inhibitor of human immunodeficiency virus reverse transcriptase.}, volume = {38}, number = {6}, pages = {766--770}, year = {1990}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Ribavirin inhibits the human immunodeficiency virus reverse transcriptase in an in vitro reaction. Ribavirin-5{\textquoteright}-diphosphate was close to 40\% more inhibitory than ribavirin-5{\textquoteright}-triphosphate. Unphosphorylated ribavirin had a reduced, but detectable, effect as an inhibitor, compared with the phosphorylated forms. The compounds seem to have a direct effect on the viral polymerase, and no chain termination was observed in the presence of ribavirin-5{\textquoteright}-triphosphate. Combination of any of the ribavirin derivatives tested with 3{\textquoteright}-azido-3{\textquoteright}-deoxythymidine (zidovudine)-5{\textquoteright}-triphosphate resulted in an increase of its anti-human immunodeficiency virus reverse transcriptase activity in the in vitro assay.}, issn = {0026-895X}, URL = {https://molpharm.aspetjournals.org/content/38/6/766}, eprint = {https://molpharm.aspetjournals.org/content/38/6/766.full.pdf}, journal = {Molecular Pharmacology} }