TY - JOUR T1 - Conformational Changes of Acetylcholinesterase JF - Molecular Pharmacology JO - Mol Pharmacol SP - 104 LP - 107 VL - 4 IS - 1 AU - RICHARD J. KITZ AU - LEON T. KREMZNER Y1 - 1968/01/01 UR - http://molpharm.aspetjournals.org/content/4/1/104.abstract N2 - The conformation of highly purified acetylcholinesterase was measured with a spectropolarimeter. It was demonstrated that heat, strong base, a substrate, and anticholinesterase agents induce alterations in the conformation of this enzyme. ACKNOWLEDGMENT This study was supported in part by National Institutes of Health grants GM09069-05, NB 05184, and PH 446454; and National Science Foundation grant GB 5362. ER -