TY - JOUR T1 - Oxidation of Indene in Liver Microsomes JF - Molecular Pharmacology JO - Mol Pharmacol SP - 201 LP - 207 VL - 4 IS - 3 AU - KENNETH C. LEIBMAN AU - ELSA ORTIZ Y1 - 1968/05/01 UR - http://molpharm.aspetjournals.org/content/4/3/201.abstract N2 - The oxidation of indene to trans-1,2-dihydroxyindane in liver preparations in vitro has been demonstrated. The reaction was mediated by liver microsomes of rats and rabbits in the presence of NADPH-generating systems. The oxidizing activity of the microsomes was markedly enhanced after pretreatment of the animals with phenobarbital. No cis-1,2-dihydroxyindane was found by methods which could have detected it at a level 0.5% of that of the trans-diol present in the reaction product. The cis-diol was not converted to its trans-isomer in the assay system. Indene epoxide was hydrated to trans-1,2-dihydroxyindane in the same in vitro system. ACKNOWLEDGMENT This work was supported by U.S. Public Health Service Grant No. UI 00453 (formerly OH 00251). ER -