RT Journal Article
SR Electronic
T1 Oxidation of Indene in Liver Microsomes
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 201
OP 207
VO 4
IS 3
A1 LEIBMAN, KENNETH C.
A1 ORTIZ, ELSA
YR 1968
UL http://molpharm.aspetjournals.org/content/4/3/201.abstract
AB The oxidation of indene to trans-1,2-dihydroxyindane in liver preparations in vitro has been demonstrated. The reaction was mediated by liver microsomes of rats and rabbits in the presence of NADPH-generating systems. The oxidizing activity of the microsomes was markedly enhanced after pretreatment of the animals with phenobarbital. No cis-1,2-dihydroxyindane was found by methods which could have detected it at a level 0.5% of that of the trans-diol present in the reaction product. The cis-diol was not converted to its trans-isomer in the assay system. Indene epoxide was hydrated to trans-1,2-dihydroxyindane in the same in vitro system. ACKNOWLEDGMENT This work was supported by U.S. Public Health Service Grant No. UI 00453 (formerly OH 00251).