RT Journal Article
SR Electronic
T1 Changes in Liver Cytoplasmic RNA after Administration of 3-Methylcholanthrene
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 218
OP 223
VO 4
IS 3
A1 BRESNICK, EDWARD
A1 SYNERHOLM, MARTHA E.
A1 TIZARD, GARY T.
YR 1968
UL http://molpharm.aspetjournals.org/content/4/3/218.abstract
AB The administration of 3-methylcholanthrene to rats is accompanied by an increase in the incorporation of orotic acid-14C into the 45 S cytoplasmic particle in the liver. The elevation reaches a maximum at 15 hr after the injection of the polycyclic hydrocarbon and diminishes to control values by 36 hr. This effect was also observed in adrenalectomized animals, eliminating any role of the adrenal corticosteroids in the phenomenon. In addition, the turnover of 18 and 28 S ribosomal RNA in liver cytoplasm was elevated after administration of the polycyclic hydrocarbon. These results suggest that the synthesis of ribosomal constituents, in particular, ribosomal RNA, may play an important role in the "induction" phenomenon observed in liver after administration of 3-methylcholanthrene. ACKNOWLEDGMENT This investigation was supported by a grant from the American Cancer Society, E-373.