PT  - JOURNAL ARTICLE
AU  - Cantoni, O
AU  - Sestili, P
AU  - Guidarelli, A
AU  - Giacomoni, P U
AU  - Cattabeni, F
TI  - Effects of L-histidine on hydrogen peroxide-induced DNA damage and cytotoxicity in cultured mammalian cells.
DP  - 1992 May 01
TA  - Molecular Pharmacology
PG  - 969--974
VI  - 41
IP  - 5
4099  - http://molpharm.aspetjournals.org/content/41/5/969.short
4100  - http://molpharm.aspetjournals.org/content/41/5/969.full
SO  - Mol Pharmacol1992 May 01; 41
AB  - L-Histidine markedly increased the growth- and DNA synthesis-inhibitory effects elicited by hydrogen peroxide in cultured Chinese hamster ovary cells. DNA single-strand breakage was also higher in the presence of the amino acid and, in addition, these breaks were characterized by a slower rate of repair, compared with that of the breaks generated by the oxidant alone. In the presence of L-histidine, hydrogen peroxide also produced DNA double-strand breakage, a lesion that cannot be detected in cells treated with even exceedingly high concentrations of the oxidant alone. Data reported herein suggest that the L-histidine-mediated increase of the cytotoxic response of cultured Chinese hamster ovary cells to hydrogen peroxide may be at least partially dependent on the formation of DNA double-strand breaks.