RT Journal Article
SR Electronic
T1 Regulation of Histidine Decarboxylase in Rat Stomach by Gastrin: the Effect of Inhibitors of Protein Synthesis
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 187
OP 195
VO 4
IS 2
A1 SOLOMON H. SNYDER
A1 LEON EPPS
YR 1968
UL http://molpharm.aspetjournals.org/content/4/2/187.abstract
AB Histidine decarboxylase activities in the stomachs of freely feeding rats or fasted rats treated with gastrin are 3 and 2 times, respectively, greater than enzyme activity of fasted rats. Administration of gastrin produces a marked increase of gastric histidine decarboxylase in 30 min with maximal effects between 2 and 3 hr, and a decline of enzyme activity to fasting levels after 8 hr. Puromycin and cycloheximide completely prevent the rise of gastric histidine decarboxylase activity induced by gastrin, whereas actinomycin D tends to stimulate this rise in activity. When cycloheximide is administered to freely feeding rats there is an exponential fall in gastric histidine decarboxylase activity with a half-life of 2.1 hr. Cycloheximide treatment accelerates the decline of gastric histidine decarboxylase activity after enhancement by gastrin. ACKNOWLEDGMENT This research was supported by USPHS grants TO 1-MH-11267 and 1 RO1 NB 07275. Solomon H. Snyder is a recipient of NIMH Research Career Development Award 5 KO3-MH-33128.