PT - JOURNAL ARTICLE AU - R Koike AU - I Miki AU - M Otoshi AU - T Totsuka AU - H Inoue AU - H Kase AU - I Saito AU - N Miyasaka TI - Gold sodium thiomalate down-regulates intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression on vascular endothelial cells. DP - 1994 Oct 01 TA - Molecular Pharmacology PG - 599--604 VI - 46 IP - 4 4099 - http://molpharm.aspetjournals.org/content/46/4/599.short 4100 - http://molpharm.aspetjournals.org/content/46/4/599.full SO - Mol Pharmacol1994 Oct 01; 46 AB - We examined whether antirheumatic drugs alter cytokine- or lipopolysaccharide-induced expression of adhesion molecules on vascular endothelial cells. Human umbilical cord vein endothelial cells were co-cultured with various antirheumatic drugs in the presence of inflammatory cytokines, and adhesion molecule expression was measured by cell enzyme-linked immunosorbent assay and Northern blot analysis. Among these antirheumatic drugs, gold sodium thiomalate significantly inhibited intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression on vascular endothelial cells and suppressed cellular binding between human monocytic cell lines, including U937 and HL-60 cells, and interleukin-1 beta-stimulated vascular endothelial cells. It is speculated that down-regulation of adhesion molecules might be one of the novel mechanisms of action of gold sodium thiomalate.