RT Journal Article
SR Electronic
T1 Hydrogen Peroxide Detoxication by Glutathione Peroxidase and Catalase in Rat Liver Homogenates
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 574
OP 579
VO 4
IS 6
A1 PAUL HOCHSTEIN
A1 HENRY UTLEY
YR 1968
UL http://molpharm.aspetjournals.org/content/4/6/574.abstract
AB The activity of glutathione peroxidase (H2O2:glutathione oxidoreductase, EC 1.11.1.9) has been studied in the soluble supernatant fractions prepared from rat liver homogenates. Enzyme activity may be demonstrated in the presence of active as well as inhibited catalase. The findings are compatible with an essential function for hepatic glutathione peroxidase in the detoxication of intracellular hydrogen peroxide, and with the view that hydrogen peroxide is the common toxic agent in the drug-induced anemia associated with a genetic deficiency of erythrocyte glucose 6-phosphate dehydrogenase. The experiments also suggest a potential role for glutathione peroxidase in regulating cellular metabolism via pentose shunt control.