PT  - JOURNAL ARTICLE
AU  - Honkakoski, Paavo
AU  - Moore, Rick
AU  - Washburn, Kimberly A.
AU  - Negishi, Masahiko
TI  - Activation by Diverse Xenochemicals of the 51-Base Pair Phenobarbital-Responsive Enhancer Module in the <em>CYP2B10</em>Gene
AID  - 10.1124/mol.53.4.597
DP  - 1998 Apr 01
TA  - Molecular Pharmacology
PG  - 597--601
VI  - 53
IP  - 4
4099  - http://molpharm.aspetjournals.org/content/53/4/597.short
4100  - http://molpharm.aspetjournals.org/content/53/4/597.full
SO  - Mol Pharmacol1998 Apr 01; 53
AB  - By extending previous studies of the phenobarbital (PB)-responsive 132-base pair (bp) enhancer sequence in the CYP2B10gene, we have delimited a 51-bp enhancer element that is fully inducible by PB in mouse primary hepatocytes. Sixteen structurally unrelated phenobarbital-type inducers activated the 51-bp enhancer element in transient transfection assays. The results thus indicate that most PB-type inducers, if not all inducers, increase the transcription of the CYP2B10 gene by activating this 51-bp element, now designated PB-responsive enhancer module or PBREM.