RT Journal Article
SR Electronic
T1 Activation by Diverse Xenochemicals of the 51-Base Pair Phenobarbital-Responsive Enhancer Module in the <em>CYP2B10</em>Gene
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 597
OP 601
DO 10.1124/mol.53.4.597
VO 53
IS 4
A1 Honkakoski, Paavo
A1 Moore, Rick
A1 Washburn, Kimberly A.
A1 Negishi, Masahiko
YR 1998
UL http://molpharm.aspetjournals.org/content/53/4/597.abstract
AB By extending previous studies of the phenobarbital (PB)-responsive 132-base pair (bp) enhancer sequence in the CYP2B10gene, we have delimited a 51-bp enhancer element that is fully inducible by PB in mouse primary hepatocytes. Sixteen structurally unrelated phenobarbital-type inducers activated the 51-bp enhancer element in transient transfection assays. The results thus indicate that most PB-type inducers, if not all inducers, increase the transcription of the CYP2B10 gene by activating this 51-bp element, now designated PB-responsive enhancer module or PBREM.