TY - JOUR T1 - Activation by Diverse Xenochemicals of the 51-Base Pair Phenobarbital-Responsive Enhancer Module in the <em>CYP2B10</em>Gene JF - Molecular Pharmacology JO - Mol Pharmacol SP - 597 LP - 601 DO - 10.1124/mol.53.4.597 VL - 53 IS - 4 AU - Paavo Honkakoski AU - Rick Moore AU - Kimberly A. Washburn AU - Masahiko Negishi Y1 - 1998/04/01 UR - http://molpharm.aspetjournals.org/content/53/4/597.abstract N2 - By extending previous studies of the phenobarbital (PB)-responsive 132-base pair (bp) enhancer sequence in the CYP2B10gene, we have delimited a 51-bp enhancer element that is fully inducible by PB in mouse primary hepatocytes. Sixteen structurally unrelated phenobarbital-type inducers activated the 51-bp enhancer element in transient transfection assays. The results thus indicate that most PB-type inducers, if not all inducers, increase the transcription of the CYP2B10 gene by activating this 51-bp element, now designated PB-responsive enhancer module or PBREM. ER -