@article {Contos1188, author = {James J. A. Contos and Isao Ishii and Jerold Chun}, title = {Lysophosphatidic Acid Receptors}, volume = {58}, number = {6}, pages = {1188--1196}, year = {2000}, doi = {10.1124/mol.58.6.1188}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression. LPA acts through specific G protein-coupled, seven-transmembrane domain receptors. To date, three mammalian cognate receptor genes,lp A1/vzg-1/Edg2,lp A2/Edg4, andlp A3/Edg7, have been identified that encode high-affinity LPA receptors. Here, we review current knowledge on these LPA receptors, including their isolation, function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles.}, issn = {0026-895X}, URL = {https://molpharm.aspetjournals.org/content/58/6/1188}, eprint = {https://molpharm.aspetjournals.org/content/58/6/1188.full.pdf}, journal = {Molecular Pharmacology} }