%0 Journal Article %A Aslamuzzaman Kazi %A David M. Smith %A Qing Zhong %A Q. Ping Dou %T Inhibition of Bcl-XL Phosphorylation by Tea Polyphenols or Epigallocatechin-3-Gallate Is Associated with Prostate Cancer Cell Apoptosis %D 2002 %R 10.1124/mol.62.4.765 %J Molecular Pharmacology %P 765-771 %V 62 %N 4 %X Prostate cancer cells demonstrate slow growth kinetics and chemoresistance. Tea polyphenols have been shown to exert prostate cancer-preventative effects. Here we report that growth-arrested prostate cancer cells expressed high levels of a hyperphosphorylated Bcl-XL in mitochondria. Treatment with tea polyphenols or the major tea component epigallocatechin-3-gallate blocked expression of the hyper-, but not hypophosphorylated Bcl-XL in mitochondria, accompanied by cytochrome c release, caspase activation, and apoptosis. Studies using specific inhibitors suggest that tea inhibits p38 mitogen-activated protein kinase and the proteasome activities, leading to inhibition of Bcl-XLphosphorylation and induction of prostate cancer cell death. %U https://molpharm.aspetjournals.org/content/molpharm/62/4/765.full.pdf