PT  - JOURNAL ARTICLE
AU  - Kazi, Aslamuzzaman
AU  - Smith, David M.
AU  - Zhong, Qing
AU  - Dou, Q. Ping
TI  - Inhibition of Bcl-X<sub>L</sub> Phosphorylation by Tea Polyphenols or Epigallocatechin-3-Gallate Is Associated with Prostate Cancer Cell Apoptosis
AID  - 10.1124/mol.62.4.765
DP  - 2002 Oct 01
TA  - Molecular Pharmacology
PG  - 765--771
VI  - 62
IP  - 4
4099  - http://molpharm.aspetjournals.org/content/62/4/765.short
4100  - http://molpharm.aspetjournals.org/content/62/4/765.full
SO  - Mol Pharmacol2002 Oct 01; 62
AB  - Prostate cancer cells demonstrate slow growth kinetics and chemoresistance. Tea polyphenols have been shown to exert prostate cancer-preventative effects. Here we report that growth-arrested prostate cancer cells expressed high levels of a hyperphosphorylated Bcl-XL in mitochondria. Treatment with tea polyphenols or the major tea component epigallocatechin-3-gallate blocked expression of the hyper-, but not hypophosphorylated Bcl-XL in mitochondria, accompanied by cytochrome c release, caspase activation, and apoptosis. Studies using specific inhibitors suggest that tea inhibits p38 mitogen-activated protein kinase and the proteasome activities, leading to inhibition of Bcl-XLphosphorylation and induction of prostate cancer cell death.