RT Journal Article
SR Electronic
T1 Altered Glycosidase Levels in Drug-Resistant Mouse Leukemias
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 345
OP 349
VO 6
IS 4
A1 H. BRUCE BOSMANN
A1 DAVID KESSEL
YR 1970
UL http://molpharm.aspetjournals.org/content/6/4/345.abstract
AB Sublines of transplantable mouse leukemias made resistant to actinomycin D, vincristine, and related antitumor agents show reduced levels of 10 glycosidases when compared with parent cell lines. Since glycosidases may be involved in the metabolism of membrane glycoproteins, resistance to these drugs may be related to changes in membrane permeability. ACKNOWLEDGMENTS The tumor lines were supplied initially by Mr. I. Wodinsky. The assistance of Dr. William De-Wys, Miss Regina Bruns, and Mrs. Marge Richter in the propagation and isolation of tumor cells is acknowledged. Mrs. Gerilyn Pike, Mr. Kenneth Case, and Mr. David Zogg assisted with the experimental determinations.