RT Journal Article
SR Electronic
T1 Metabolic Conversion of Heliotridine-Based Pyrrolizidine Alkaloids to Dehydroheliotridine
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 402
OP 406
VO 6
IS 4
A1 M. V. JAGO
A1 J. A. EDGAR
A1 L. W. SMITH
A1 C. C. J. CULVENOR
YR 1970
UL http://molpharm.aspetjournals.org/content/6/4/402.abstract
AB The heliotridine-based pyrrolizidine alkaloids lasiocarpine and heliotrine were metabolized in vitro by rat liver microsomes to one main chloroform-extractable and water-soluble pyrrolic derivative, which was isolated and idenitified as dehydroheliotridine (6,7-dihydro-7α-hydroxy-1-hydroxymethyl-5H-pyrrolizine) by chromatography and nuclear magnetic resonance and mass spectroscopy. Only trace amounts of this metabolite were formed from the N-oxides of lasiocarpine or heliotrine, and it was not formed from supinine. ACKNOWLEDGMENT We wish to thank Miss K. Moss, for technical assistance.