TY - JOUR T1 - Constitutive Activity and Inverse Agonists of G Protein-Coupled Receptors: a Current Perspective JF - Molecular Pharmacology JO - Mol Pharmacol SP - 1271 LP - 1276 DO - 10.1124/mol.64.6.1271 VL - 64 IS - 6 AU - Graeme Milligan Y1 - 2003/12/01 UR - http://molpharm.aspetjournals.org/content/64/6/1271.abstract N2 - Over the last decade, the ability to detect agonist-independent signal transduction by G protein-coupled receptors has in turn resulted in the detection and study of ligands able to block this activity. Such ligands are generically described as inverse agonists. Considerable attention has recently been devoted to the presence and roles of endogenous antagonist/inverse agonists and the concept that inverse agonists may have specific therapeutic benefits compared with neutral antagonists. ER -