TY - JOUR T1 - 2-Amino-4-hydroxyquinazolines as Inhibitors of Thymidylate Synthetase JF - Molecular Pharmacology JO - Mol Pharmacol SP - 573 LP - 575 VL - 6 IS - 5 AU - ORSON D. BIRD AU - JOHN W. VAITKUS AU - JANE CLARKE Y1 - 1970/09/01 UR - http://molpharm.aspetjournals.org/content/6/5/573.abstract N2 - This paper describes a 2-amino-4-hydroxyquinazoline analogue of folic acid which is much stronger than methotrexate as a thymidylate synthetase inhibitor but weaker as a dihydrofolate reductase inhibitor. It also identifies the requirements of certain structural moieties for this activity. ER -