PT  - JOURNAL ARTICLE
AU  - Graeme Milligan
TI  - G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
AID  - 10.1124/mol.104.000497
DP  - 2004 Jul 01
TA  - Molecular Pharmacology
PG  - 1--7
VI  - 66
IP  - 1
4099  - http://molpharm.aspetjournals.org/content/66/1/1.short
4100  - http://molpharm.aspetjournals.org/content/66/1/1.full
SO  - Mol Pharmacol2004 Jul 01; 66
AB  - It is now generally accepted that G protein-coupled receptors (GPCRs) can exist as dimers or as part of larger oligomeric complexes. Increasing evidence suggests that a dimer is the minimal functional structure, but considerable variation exists between reports of the effects of agonist ligands on quaternary structure. Many studies have intimated the existence of heterodimeric GPCR pairings. Key questions that remain to be addressed effectively include the prevalence and relevance of these in native tissues and the implications of heterodimerization for pharmacology and, potentially, for drug design.