PT - JOURNAL ARTICLE AU - Jesse Strock AU - María A. Diversé-Pierluissi TI - Ca<sup>2+</sup> Channels As Integrators of G Protein-Mediated Signaling in Neurons AID - 10.1124/mol.104.002261 DP - 2004 Nov 01 TA - Molecular Pharmacology PG - 1071--1076 VI - 66 IP - 5 4099 - http://molpharm.aspetjournals.org/content/66/5/1071.short 4100 - http://molpharm.aspetjournals.org/content/66/5/1071.full SO - Mol Pharmacol2004 Nov 01; 66 AB - The observations from Dunlap and Fischbach that transmitter-mediated shortening of the duration of action potentials could be caused by a decrease in calcium conductance led to numerous studies of the mechanisms of modulation of voltage-dependent calcium channels. Calcium channels are well known targets for inhibition by receptor-G protein pathways, and multiple forms of inhibition have been described. Inhibition of Ca2+ channels can be mediated by G protein βγ-subunits or by kinases, such as protein kinase C and tyrosine kinases. In the last few years, it has been shown that integration of G protein signaling can take place at the level of the calcium channel by regulation of the interaction of the channel pore-forming subunit with different cellular proteins.