TY - JOUR T1 - Targeting Ischemic Stroke with a Novel Opener of ATP-Sensitive Potassium Channels in the Brain JF - Molecular Pharmacology JO - Mol Pharmacol SP - 1160 LP - 1168 DO - 10.1124/mol.104.003178 VL - 66 IS - 5 AU - Hai Wang AU - Ying-li Zhang AU - Xing-Chun Tang AU - Hua-Song Feng AU - Gang Hu Y1 - 2004/11/01 UR - http://molpharm.aspetjournals.org/content/66/5/1160.abstract N2 - During cerebral ischemia, the opening of neuronal ATP-sensitive potassium channels (KATP channels) affords intrinsic protection by regulating membrane potential. To augment this endogenous mechanism, we have synthesized iptakalim, a KATP opener. Through KATP channel activation, iptakalim affected multiple pathways of the glutamatergic system, limiting glutamate release and receptor actions, which are involved in excitotoxicity during ischemic damage. The molecule readily penetrated the brain and showed low toxicity in animal experiments. In different animal models of stroke as well as in cell cultures, iptakalim provided significant neuroprotection, not only in promoting behavioral recovery but also in protecting neurons against necrosis and apoptosis. This compound thus has promise as a neuroprotective drug for the treatment of stroke and other forms of neuronal damage. ER -