PT  - JOURNAL ARTICLE
AU  - Satish A. Eraly
AU  - Kevin T. Bush
AU  - Rosemary V. Sampogna
AU  - Vibha Bhatnagar
AU  - Sanjay K. Nigam
TI  - The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA?
AID  - 10.1124/mol.65.3.479
DP  - 2004 Mar 01
TA  - Molecular Pharmacology
PG  - 479--487
VI  - 65
IP  - 3
4099  - http://molpharm.aspetjournals.org/content/65/3/479.short
4100  - http://molpharm.aspetjournals.org/content/65/3/479.full
SO  - Mol Pharmacol2004 Mar 01; 65
AB  - Renal organic anion secretion has been implicated in numerous clinically significant drug interactions and adverse reactions, indicating the importance of a detailed understanding of this pathway for the development of optimum therapeutics. With the cloning of multiple genes encoding organic anion transporters (OATs), the study of organic anion secretion has entered the molecular age. In this review, we focus on various aspects of the molecular biology and pharmacology of the OATs, including discussion of their structural biology, genomic organization in pairs, developmental regulation, toxicology, and pharmacogenetics. We propose functional, pathophysiological, and evolutionary hypotheses to help explain recent experimental and genomic data.