TY - JOUR T1 - Chromatin Remodeling: A Novel Mechanism of Psychotropic Drug Action JF - Molecular Pharmacology JO - Mol Pharmacol SP - 440 LP - 443 DO - 10.1124/mol.106.027078 VL - 70 IS - 2 AU - Samuel S. Newton AU - Ronald S. Duman Y1 - 2006/08/01 UR - http://molpharm.aspetjournals.org/content/70/2/440.abstract N2 - Regulation of gene expression is known to contribute to the long-term adaptations underlying the effects of psychotropic drugs, including the actions of antidepressants and drugs of abuse in behavioral models. However, the precise molecular events that are required for modification of chromatin and that underlie gene repression or activation have not been elucidated. Recent reports, including the article by Cassel et al. (p. 487) in this issue of Molecular Pharmacology, address this question and demonstrate that psychotropic drugs modify specific methyl-CpG-binding proteins that control histone acetylation and gene expression. ER -