RT Journal Article SR Electronic T1 Apigenin Inhibits Immunostimulatory Function of Dendritic Cells: Implication of Immunotherapeutic Adjuvant JF Molecular Pharmacology JO Mol Pharmacol FD American Society for Pharmacology and Experimental Therapeutics SP 1033 OP 1044 DO 10.1124/mol.106.024547 VO 70 IS 3 A1 Man-Soo Yoon A1 Jun Sik Lee A1 Byoung-Moon Choi A1 Young-Il Jeong A1 Chang-Min Lee A1 Jong-Hoon Park A1 Yuseok Moon A1 Si-Chan Sung A1 Sang Kwon Lee A1 Yun Hee Chang A1 Hae Young Chung A1 Yeong-Min Park YR 2006 UL http://molpharm.aspetjournals.org/content/70/3/1033.abstract AB Apigenin, one of the most common flavonoids, has been shown to possess anti-inflammatory, anticarcinogenic, and free radical-scavenging properties. However, the influence of apigenin on the immunostimulatory effects and maturation of dendritic cells (DC) remains, for the most part, unknown. In this study, we have attempted to ascertain whether apigenin influences the expression of surface molecules, dextran uptake, cytokine production, and T-cell differentiation as well as the signaling pathways underlying these phenomena in murine bone marrow-derived DC. In the presence of apigenin, CD80, CD86, and major histocompatibility complex class I and II molecules, expressions on DC were significantly suppressed, and lipopolysaccharide (LPS)-induced interleukin (IL)-12 expression was impaired. The DC proved highly efficient at antigen capture, as evidenced by the observation of mannose receptor-mediated endocytosis in the presence of apigenin. The LPS-induced activation of mitogen-activated protein kinase, the nuclear translocation of its nuclear factor-κB p65 subunit, and the induction of the T-helper 1 response were all impaired in the presence of apigenin, whereas the cell-mediated immune response remained normal. These findings provide new insight into the immunopharmacological functions of apigenin and its effects on DC, and they may also prove useful in the development of adjuvant therapies for individuals suffering from acute or chronic DC-associated diseases. The American Society for Pharmacology and Experimental Therapeutics