RT Journal Article
SR Electronic
T1 Effect of Hypophysectomy on Adrenal Dopamine β-Hydroxylase Activity in the Rat
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 163
OP 168
VO 7
IS 2
A1 GEWIRTZ, GEORGE P.
A1 KEVETŇANSKÝ, RICHARD
A1 WEISE, VIRGINIA K
A1 KOPIN, IRWIN J.
YR 1971
UL http://molpharm.aspetjournals.org/content/7/2/163.abstract
AB Dopamine β-hydroxylase activity in the adrenal medulla is decreased 1 week after hypophysectomy. This activity can be restored by treatment with either adrenocorticotropin or dexamethasone. Adrenal denervation also decreases adrenal dopamine β-hydroxylase activity and prevents elevation of this enzyme in response to immobilization. Intact pituitary-adrenal and neuronal systems are required to maintain normal adrenal dopamine β-hydroxylase levels nonimmobilized rats and to raise the levels in immobilized rats. ACKNOWLEDGMENT We are grateful to Mrs. Darina Kvetňanská for her excellent technical assistance.