PT  - JOURNAL ARTICLE
AU  - William L. Holland
AU  - Philipp E. Scherer
TI  - PAQRs: A Counteracting Force to Ceramides?
AID  - 10.1124/mol.109.054817
DP  - 2009 Apr 01
TA  - Molecular Pharmacology
PG  - 740--743
VI  - 75
IP  - 4
4099  - http://molpharm.aspetjournals.org/content/75/4/740.short
4100  - http://molpharm.aspetjournals.org/content/75/4/740.full
SO  - Mol Pharmacol2009 Apr 01; 75
AB  - In recent years, sphingolipids have garnered increasing attention for their roles in modulating intracellular signaling events. Circulating factors associated with obesity promote excess accumulation of ceramide or glucosylceramide derivatives, which impair insulin action in peripheral tissues. In this issue, Villa et al. (p. 866) provide evidence that, in yeast, the progestin and adipoQ receptor superfamily of receptors mediate their effects via a novel ceramidase activity, generating sphingoid base as a second messenger. The American Society for Pharmacology and Experimental Therapeutics