PT  - JOURNAL ARTICLE
AU  - Jamie L. McConnell
AU  - Brian E. Wadzinski
TI  - Targeting Protein Serine/Threonine Phosphatases for Drug Development
AID  - 10.1124/mol.108.053140
DP  - 2009 Jun 01
TA  - Molecular Pharmacology
PG  - 1249--1261
VI  - 75
IP  - 6
4099  - http://molpharm.aspetjournals.org/content/75/6/1249.short
4100  - http://molpharm.aspetjournals.org/content/75/6/1249.full
SO  - Mol Pharmacol2009 Jun 01; 75
AB  - With the recent clinical success of drugs targeting protein kinase activity, drug discovery efforts are focusing on the role of reversible protein phosphorylation in disease states. The activity of protein phosphatases, enzymes that oppose protein kinases, can also be manipulated to alter cellular signaling for therapeutic benefits. In this review, we present protein serine/threonine phosphatases as viable therapeutic targets, discussing past successes, current challenges, and future strategies for modulating phosphatase activity. The American Society for Pharmacology and Experimental Therapeutics