@article {Zhang396, author = {Lifen Zhang and William M. Doyon and Jeremy J. Clark and Paul E. M. Phillips and John A. Dani}, title = {Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum}, volume = {76}, number = {2}, pages = {396--404}, year = {2009}, doi = {10.1124/mol.109.056317}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Dopamine (DA) release varies within subregions and local environments of the striatum, suggesting that controls intrinsic and extrinsic to the DA fibers and terminals regulate release. While applying fast-scan cyclic voltammetry and using tonic and phasic stimulus trains, we investigated the regulation of DA release in the dorsolateral to ventral striatum. The ratio of phasic-to-tonic-evoked DA signals varied with the average ongoing firing frequency, and the ratio was generally higher in the nucleus accumbens (NAc) compared with the dorsolateral striatum. At the normal average firing frequency, burst stimulation produces a larger increase in the DA response in the NAc than the dorsolateral striatum. This finding was comparable whether the DA measurements were made using in vitro brain slices or were recorded in vivo from freely moving rodents. Blockade of the dopamine transporters and dopamine D2 receptors particularly enhanced the tonic DA signals. Conversely, blockade of nicotinic acetylcholine receptors (nAChRs) containing the β2 subunit (β2*) predominantly suppressed tonic DA signals. The suppression of tonic DA release increased the contrast between phasic and tonic DA signals, and that made the frequency-dependent DA dynamics between the dorsolateral striatum and NAc more similar. The results indicate that intrinsic differences in the DA fibers that innervate specific regions of the striatum combine with (at least) DA transporters, DA receptors, and nAChRs to regulate the frequency dependence of DA release. A combination of mechanisms provides specific local control of DA release that underlies pathway-specific information associated with motor and reward-related functions.}, issn = {0026-895X}, URL = {https://molpharm.aspetjournals.org/content/76/2/396}, eprint = {https://molpharm.aspetjournals.org/content/76/2/396.full.pdf}, journal = {Molecular Pharmacology} }