PT  - JOURNAL ARTICLE
AU  - KENNETH BALKOW
AU  - MARCO RABINOVITZ
TI  - Increased Binding of Transfer Ribonucleic Acid Species to Ribosomes under Conditions Interfering with Their Aminoacylation
DP  - 1973 Mar 01
TA  - Molecular Pharmacology
PG  - 229--236
VI  - 9
IP  - 2
4099  - http://molpharm.aspetjournals.org/content/9/2/229.short
4100  - http://molpharm.aspetjournals.org/content/9/2/229.full
SO  - Mol Pharmacol1973 Mar 01; 9
AB  - The α-amino alcohols, histidinol and valinol, inhibited protein synthesis in the rabbit reticulocyte cell-free system by interfering with activation of histidine and valine, respectively. The lower rate of translation resulted in an increase in the polyribosome component of such systems. Histidinol promoted an accumulation of tRNAHis associated with ribosomes, and a similar result was found with valinol. The data indicate that deacylated tRNA is bound to ribosomes in a protein-synthesizing system when the acylated form is unavailable.