PT  - JOURNAL ARTICLE
AU  - JAMES L. BENNETT
AU  - ERNEST BUEDING
TI  - Uptake of 5-Hydroxytryptamine by <em>Schistosoma mansoni</em>
DP  - 1973 May 01
TA  - Molecular Pharmacology
PG  - 311--319
VI  - 9
IP  - 3
4099  - http://molpharm.aspetjournals.org/content/9/3/311.short
4100  - http://molpharm.aspetjournals.org/content/9/3/311.full
SO  - Mol Pharmacol1973 May 01; 9
AB  - In spite of the presence of high concentrations of 5-hydroxytryptamine (5-HT) in Schistosoma mansoni, synthesis of this amine by the parasite could not be demonstrated. The worm has a high- and a low-affinity uptake mechanism (below and above 2 µM, respectively) for 5-HT. The high-affinity uptake mechanism provides the parasite with a means to obtain 5-HT, even at the low concentrations of this amine prevailing in the physiological environment of the worm. ACKNOWLEDGMENT We are indebted to Dr. A. H. Glässer of Farmitalia for the 8β[(carbobenzoxyamino)methyl]-1,6-dimethyl-l0α-ergotine used in this study.