RT Journal Article
SR Electronic
T1 Comparative Study of Estrogen Action
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 520
OP 533
VO 9
IS 4
A1 JEAN-PIERRE RAYNAUD
A1 MARIE-MADELEINE BOUTON
A1 DANIELLE GALLET-BOURQUIN
A1 DANIEL PHILIBERT
A1 COLETTE TOURNEMINE
A1 GENEVIÈVE AZADIAN-BOULANGER
YR 1973
UL http://molpharm.aspetjournals.org/content/9/4/520.abstract
AB By comparing 16 estradiol derivatives, it has been possible to assess the relative influence of distribution, metabolism, uterine uptake, and plasma and tissue binding on uterotrophic activity in the rat. This comparison has revealed that all active compounds are bound in vivo to the 8 S uterus cytosol receptor, but that their activity cannot be related to binding in vitro, owing to the many factors acting on the compound in vivo prior to the triggering of the biological response. It is suggested that only the free molecule in the plasma is active on the uterus and that consequently activity is modulated by plasma binding.