@article {OESCH692, author = {FRANZ OESCH and NOREEN MORRIS and JOHN W. DALY and JACQUES E. GIELEN and DANIEL W. NEBERT}, title = {Genetic Expression of the Induction of Epoxide Hydrase and Aryl Hydrocarbon Hydroxylase Activities in the Mouse by Phenobarbital or 3-Methylcholanthrene}, volume = {9}, number = {5}, pages = {692--696}, year = {1973}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Intraperitoneal administration of phenobarbital causes significant induction of hepatic epoxide hydrase activity in C57BL/6N, C3H/HeN, NZB/BLN, and NZW/BLN inbred strains of mice and not in DBA/2N, N:GP(SW), and AL/N strains, whereas a hepatic monooxygenase [aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity is stimulated 1.5-3-fold in all seven strains. Intraperitoneal administration of 3-methylcholanthrene has virtually no effect on the hydrase activity in any of the seven strains. The aromatic hydrocarbon increases the hydroxylase activity 2-6-fold in C57BL/6N, N:GP(SW), AL/N, and C3H/HeN mice but causes no significant rise in the hepatic enzyme activity in DBA/2N, NZB/BLN, and NZW/BLN mice. In appropriate crosses between C57BL/6N and DBA/2N, the expression of epoxide hydrase induction by phenobarbital appears so complex as to preclude any simple genetic analysis; the basal hydrase levels appear to be inherited additively.}, issn = {0026-895X}, URL = {https://molpharm.aspetjournals.org/content/9/5/692}, eprint = {https://molpharm.aspetjournals.org/content/9/5/692.full.pdf}, journal = {Molecular Pharmacology} }