TY - JOUR T1 - Inhibition by Colchicine and by Vinblastine of Acetylcholine-Induced Catecholamine Release from the Adrenal Gland: an Anticholinergic Action, Not an Effect upon Microtubules JF - Molecular Pharmacology JO - Mol Pharmacol SP - 264 LP - 267 VL - 8 IS - 2 AU - J. M. TRIFARÓ AU - B. COLLIER AU - A. LASTOWECKA AU - D. STERN Y1 - 1972/03/01 UR - http://molpharm.aspetjournals.org/content/8/2/264.abstract N2 - We have confirmed that colchicine (1 mM) or vinblastine (100 µM) inhibits the acetylcholine-induced release of catecholamines from perfused bovine adrenal glands. This is an anticholinergic effect of these drugs and cannot be interpreted as evidence that microtubules participate in the release of amines, because neither colchicine nor vinblastine reduced catecholamine released by a high concentration of K+ or by angiotensin. Furthermore, both colchicine (1 mM) and vinblastine (100 µM) blocked transmission through the superior cervical ganglion of the cat by a postsynaptic anti-acetylcholine action. ER -