PT  - JOURNAL ARTICLE
AU  - Liping Hu
AU  - Xiangyang Lin
AU  - Hong Lu
AU  - Bicheng Chen
AU  - Yongheng Bai
TI  - An Overview of Hedgehog Signaling in Fibrosis
AID  - 10.1124/mol.114.095141
DP  - 2015 Feb 01
TA  - Molecular Pharmacology
PG  - 174--182
VI  - 87
IP  - 2
4099  - http://molpharm.aspetjournals.org/content/87/2/174.short
4100  - http://molpharm.aspetjournals.org/content/87/2/174.full
SO  - Mol Pharmacol2015 Feb 01; 87
AB  - The Hedgehog (Hh) signaling pathway plays a key role during embryogenesis and tissue regeneration. Recently, studies revealed that overactivated Hh signaling leads to fibrogenesis in many types of tissues. The activation of Hh signaling is involved in the epithelial-mesenchymal transition and excessive extracellular matrix deposition. Blockade of Hh signaling abolishes the induction of the epithelial-mesenchymal transition and ameliorates tissue fibrosis. Therefore, new therapeutic targets to alleviate fibrosis based on the Hh signaling have attracted a great deal of attention. This is a new strategy for treating fibrosis and other related diseases. In this review, we discuss the crucial role of Hh signaling in fibrogenesis to provide a better understanding of their relationship and to encourage the study of novel targeted therapies.