TY - JOUR T1 - Research Resources for Nuclear Receptor Signaling Pathways JF - Molecular Pharmacology JO - Mol Pharmacol SP - 153 LP - 159 DO - 10.1124/mol.116.103713 VL - 90 IS - 2 AU - Neil J. McKenna Y1 - 2016/08/01 UR - http://molpharm.aspetjournals.org/content/90/2/153.abstract N2 - Nuclear receptor (NR) signaling pathways impact cellular function in a broad variety of tissues in both normal physiology and disease states. The complex tissue-specific biology of these pathways is an enduring impediment to the development of clinical NR small-molecule modulators that combine therapeutically desirable effects in specific target tissues with suppression of off-target effects in other tissues. Supporting the important primary research in this area is a variety of web-based resources that assist researchers in gaining an appreciation of the molecular determinants of the pharmacology of a NR pathway in a given tissue. In this study, selected representative examples of these tools are reviewed, along with discussions on how current and future generations of tools might optimally adapt to the future of NR signaling research. ER -