PT  - JOURNAL ARTICLE
AU  - Daniel J. Calvo
AU  - Andrea N. Beltrán González
TI  - Dynamic Regulation of the GABA<sub>A</sub> Receptor Function by Redox Mechanisms
AID  - 10.1124/mol.116.105205
DP  - 2016 Sep 01
TA  - Molecular Pharmacology
PG  - 326--333
VI  - 90
IP  - 3
4099  - http://molpharm.aspetjournals.org/content/90/3/326.short
4100  - http://molpharm.aspetjournals.org/content/90/3/326.full
SO  - Mol Pharmacol2016 Sep 01; 90
AB  - Oxidizing and reducing agents, which are currently involved in cell metabolism and signaling pathways, can regulate fast inhibitory neurotransmission mediated by GABA receptors in the nervous system. A number of in vitro studies have shown that diverse redox compounds, including redox metabolites and reactive oxygen and nitrogen species, modulate phasic and tonic responses mediated by neuronal GABAA receptors through both presynaptic and postsynaptic mechanisms. We review experimental data showing that many redox agents, which are normally present in neurons and glia or are endogenously generated in these cells under physiologic states or during oxidative stress (e.g., hydrogen peroxide, superoxide and hydroxyl radicals, nitric oxide, ascorbic acid, and glutathione), induce potentiating or inhibiting actions on different native and recombinant GABAA receptor subtypes. Based on these results, it is thought that redox signaling might represent a homeostatic mechanism that regulates the function of synaptic and extrasynaptic GABAA receptors in physiologic and pathologic conditions.