TY - JOUR T1 - Dynamic Regulation of the GABA<sub>A</sub> Receptor Function by Redox Mechanisms JF - Molecular Pharmacology JO - Mol Pharmacol SP - 326 LP - 333 DO - 10.1124/mol.116.105205 VL - 90 IS - 3 AU - Daniel J. Calvo AU - Andrea N. Beltrán González Y1 - 2016/09/01 UR - http://molpharm.aspetjournals.org/content/90/3/326.abstract N2 - Oxidizing and reducing agents, which are currently involved in cell metabolism and signaling pathways, can regulate fast inhibitory neurotransmission mediated by GABA receptors in the nervous system. A number of in vitro studies have shown that diverse redox compounds, including redox metabolites and reactive oxygen and nitrogen species, modulate phasic and tonic responses mediated by neuronal GABAA receptors through both presynaptic and postsynaptic mechanisms. We review experimental data showing that many redox agents, which are normally present in neurons and glia or are endogenously generated in these cells under physiologic states or during oxidative stress (e.g., hydrogen peroxide, superoxide and hydroxyl radicals, nitric oxide, ascorbic acid, and glutathione), induce potentiating or inhibiting actions on different native and recombinant GABAA receptor subtypes. Based on these results, it is thought that redox signaling might represent a homeostatic mechanism that regulates the function of synaptic and extrasynaptic GABAA receptors in physiologic and pathologic conditions. ER -