RT Journal Article
SR Electronic
T1 The Prevalence, Maintenance and Relevance of GPCR Oligomerization
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP mol.113.084780
DO 10.1124/mol.113.084780
A1 Graeme Milligan
YR 2013
UL http://molpharm.aspetjournals.org/content/early/2013/04/30/mol.113.084780.abstract
AB Over the past decade ideas and experimental support for the hypothesis that G protein-coupled receptors may exist as dimeric or oligomeric complexes moved initially from heresy to orthodoxy, to the current situation in which the capacity of such receptors to interact is generally accepted but the prevalence, maintenance and relevance of such interactions to both pharmacology and function remain unclear. A vast body of data obtained following transfection of cultured cells is still to be translated to native systems and, even where this has been attempted, results often remain controversial and contradictory. This review will consider approaches that are currently being applied, why these might be challenging to interpret and suggest means to overcome these limitations.