RT Journal Article
SR Electronic
T1 Molecular Responses to Hypoxia Inducible Factor-1α and Beyond
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP mol.113.089623
DO 10.1124/mol.113.089623
A1 Yana Chervona
A1 Jason A Brocato
A1 Max Costa
YR 2014
UL http://molpharm.aspetjournals.org/content/early/2014/02/25/mol.113.089623.abstract
AB Cellular response to changes in oxygen tension during normal development or pathological processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen sensitive transcription factor. HIF activity is primarily controlled through post-translational modifications, and stabilization of HIF-1α; and HIF-2α; proteins, and is regulated by a number of cellular pathways involving both oxygen-dependent and oxygen- independent mechanisms. Stabilization of HIF-1α, in particular, activates transcription of genes that participate in key pathways in carcinogenesis, such as angiogenesis, dedifferentiation, and invasion. Since its discovery more than two decades ago, HIF-1α has become an important topic in molecular research and has been implicated not only in disease pathology, but also in it's prognosis. In this review, we will focus on recent insights into HIF-1α regulation, function and gene expression. We will also discuss emerging data on HIFs involvement in cancer prognosis and therapeutic interventions.