TY - JOUR T1 - The Complex Roles of Mu-Opioid Receptor Phosphorylation: A Key Determinant in Receptor Signaling and Regulation JF - Molecular Pharmacology JO - Mol Pharmacol DO - 10.1124/mol.115.100180 SP - mol.115.100180 AU - Meritxell Canals Y1 - 2015/01/01 UR - http://molpharm.aspetjournals.org/content/early/2015/07/07/mol.115.100180.abstract N2 - This Commentary focuses on two articles in the October 2015 issue of Molecular Pharmacology that investigate the role of mu-opioid receptor phosphorylation in receptor agonist binding and desensitization. The work of Birdsong et al. (doi:10.1124/mol.114.097527) and Yousuf et al. (doi:10.1124/mol.115.098244) clearly highlights the complexity that researchers face when trying to assess the signaling and regulatory consequences of GPCR phosphorylation. ER -