PT - JOURNAL ARTICLE AU - Laura M Bohn AU - Martin J Lohse AU - Michael Nitabach AU - Paul H Taghert AU - Martine J Smit TI - Exploring the Biology of GPCRs from In Vitro to In Vivo AID - 10.1124/mol.115.100750 DP - 2015 Jan 01 TA - Molecular Pharmacology PG - mol.115.100750 4099 - http://molpharm.aspetjournals.org/content/early/2015/07/10/mol.115.100750.1.short 4100 - http://molpharm.aspetjournals.org/content/early/2015/07/10/mol.115.100750.1.full AB - In August, 2014, an international group of researchers gathered for four days at the Lorentz Center in Leiden, the Netherlands, to explore the technical and conceptual issues associated with the analysis of G protein-coupled receptor (GPCR) functions utilizing information from crystal structure models to the use of model organisms. This collection of review articles evolved from the five day meeting with brief presentations and structured discussion periods that were designed to identify key questions remaining in understanding GPCR function and to propose novel strategies by integrating scientific disciplines, to guide future research.