%0 Journal Article %A Henry A Dunnn %A Stephen SG Ferguson %T PDZ Protein Regulation of GPCR Trafficking and Signaling Pathways %D 2015 %R 10.1124/mol.115.098509 %J Molecular Pharmacology %P mol.115.098509 %X G protein-coupled receptors (GPCRs) contribute to the regulation of every aspect of human physiology and are the therapeutic targets for the treatment of numerous diseases. As a consequence, understanding the myriad of mechanisms controlling GPCR signalling and trafficking is essential for the development of new pharmacological strategies for the treatment of human pathologies. Of the many GPCR-interacting proteins (GIPs), PDZ domain-containing proteins appear most abundant and have similarly been implicated in disease mechanisms. PDZ proteins play an important role at regulating receptor and channel protein localization of synapses and tight junctions and function to scaffold intracellular signalling protein complexes. In the current study, we review the known functional interactions between PDZ domain-containing proteins and GPCRs, and provide insight into the potential mechanisms of action. These PDZ domain-containing proteins include the membrane-associated guanylate-like kinases (MAGUKs) (PSD-95, SAP97, PSD-93, SAP102, DLG5, CARMA3, MPP3, CASK, MAGI-1, MAGI-2, MAGI-3), NHERF proteins (NHERF1, NHERF2, PDZK1, PDZK2), Golgi-associated PDZ proteins (GIPC and CAL), PDZ-GEFs (PDZ-GEF1 and PDZ-GEF2), RGS-Homology-RhoGEFs (PDZ-RhoGEF and LARG), RGS3 and RGS12, spinophilin and neurabin-1, Shank proteins (Shank1, Shank2, Shank3), Par3 and Par6, MUPP1, Tamalin, nNOS, PICK1, and SNX27. %U https://molpharm.aspetjournals.org/content/molpharm/early/2015/03/25/mol.115.098509.full.pdf